Protein: O43464 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O43464 (Uniprot)	HTRA2_HUMAN	HTRA2	Serine protease HTRA2, mitochondrial	human	No

Protein Function

Uniprot: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independ more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	270	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
270	GO:0034645	cellular macromolecule biosynthetic process
270	GO:0010467	gene expression
270	GO:0090304	nucleic acid metabolic process
270	GO:0032446	protein modification by small protein conjugation
270	GO:0060255	regulation of macromolecule metabolic process
270	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
125	GO:0005829	cytosol
125	GO:0005634	nucleus
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen
270	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006508	proteolysis	IDA
GO:0006672	ceramide metabolic process	IEA
GO:0007005	mitochondrion organization	IEA
GO:0007568	aging	IEA
GO:0007628	adult walking behavior	IEA
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP
GO:0009635	response to herbicide	IEA
GO:0010822	positive regulation of mitochondrion organization	IMP
GO:0010942	positive regulation of cell death	IDA
GO:0016540	protein autoprocessing	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000785	chromatin	IDA
GO:0005634	nucleus	IDA
GO:0005739	mitochondrion	TAS
GO:0005758	mitochondrial intermembrane space	IDA
GO:0005783	endoplasmic reticulum	NAS
GO:0005789	endoplasmic reticulum membrane	TAS
GO:0005829	cytosol	IDA
GO:0005856	cytoskeleton	IDA
GO:0009898	cytoplasmic side of plasma membrane	ISS
GO:0016020	membrane	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000785	chromatin	GO:0005783	endoplasmic reticulum	8.02e-10	1.28e-67
GO:0000785	chromatin	GO:0005789	endoplasmic reticulum membrane	2.50e-06	4.03e-103
GO:0000785	chromatin	GO:0016020	membrane	1.14e-59	2.58e-148
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005634	nucleus	GO:0005789	endoplasmic reticulum membrane	1.61e-25	3.10e-56
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0031966	mitochondrial membrane	7.12e-06	7.29e-05
GO:0005783	endoplasmic reticulum	GO:0005856	cytoskeleton	1.80e-20	2.15e-98
GO:0005789	endoplasmic reticulum membrane	GO:0005829	cytosol	4.27e-12	7.53e-04
GO:0005789	endoplasmic reticulum membrane	GO:0005856	cytoskeleton	1.07e-13	1.06e-67

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
BIRC7_HUMAN	No
DBLOH_HUMAN	Yes: Q9NR28 (MoonDB)
MK14_HUMAN	No
NDUAD_HUMAN	No
PSN1_HUMAN	No
UBP7_HUMAN	No
XIAP_HUMAN	Yes: P98170 (MoonDB)

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Publications Associated

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PMID	Article Title
10644717	Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia.
10873535	Expression, purification, and functional analysis of the human serine protease HtrA2.
10971580	Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.
10995577	Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif.
11583623	A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
11967569	Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
15200957	Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15961413	Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

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OMIM Diseases Associated

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OMIM ID	Disease Name
610297	Parkinson disease 13
617248	3-methylglutaconic aciduria 8

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Protein Domains Associated

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Domain Name	Domain ID	Source
PDZ	IPR001478	InterPro
PDZ	PS50106	PROSITE
PDZ	SM00228	SMART
PDZ_2	PF13180	Pfam
PDZ_sf	IPR036034	InterPro
Peptidase_S1_PA	IPR009003	InterPro
Peptidase_S1C	IPR001940	InterPro
PROTEASES2C	PR00834	PRINTS
SSF50156	SSF50156	SUPFAM
SSF50494	SSF50494	SUPFAM

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