Protein: P02730 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P02730 (Uniprot)	B3AT_HUMAN	SLC4A1	Band 3 anion transport protein	human	Yes

Protein Function

Uniprot: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the int more..

Dissimilar Functions Manual Curation

Function 1: Anion exchanger, electroneutral anion exchange across the cell membrane. Regulates glycolysis.

Function 2: Strutural protein binding to cytoskeletal proteins.

Publications (PMID): 8325839

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
85	GO:0016021	integral component of membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006820	anion transport	IDA
GO:0006821	chloride transport	ISS
GO:0006873	cellular ion homeostasis	TAS
GO:0015701	bicarbonate transport	TAS
GO:0035725	sodium ion transmembrane transport	IEA
GO:0051453	regulation of intracellular pH	IBA
GO:1902476	chloride transmembrane transport	IEA

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Cellular Components

Showing 1 to 8 of 8 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005886	plasma membrane	TAS
GO:0005887	integral component of plasma membrane	IDA
GO:0016021	integral component of membrane	NAS
GO:0016323	basolateral plasma membrane	IDA
GO:0030018	Z disc	ISS
GO:0030863	cortical cytoskeleton	IDA
GO:0070062	extracellular exosome	IDA
GO:0072562	blood microparticle	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ARF_HUMAN	No
AT1B1_HUMAN	No
BMP10_HUMAN	No
FHR5_HUMAN	No
G3XAG3_HUMAN	No
NADAP_HUMAN	No
Q08AM2_HUMAN	No
TMM60_HUMAN	No

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Publications Associated

Showing 1 to 10 of 68 entries

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PMID	Article Title
701248	Orientation of the band 3 polypeptide from human erythrocyte membranes. Identification of NH2-terminal sequence and site of carbohydrate attachment.
1352774	Anion-proton cotransport through the human red blood cell band 3 protein. Role of glutamate 681.
1378323	Band 3 Tuscaloosa: Pro-327-->Arg substitution in the cytoplasmic domain of erythrocyte band 3 protein associated with spherocytic hemolytic anemia and partial deficiency of protein 4.2.
1527044	A structural study of the membrane domain of band 3 by tryptic digestion. Conformational change of band 3 in situ induced by alkali treatment.
1538405	Basis of unique red cell membrane properties in hereditary ovalocytosis.
1678289	Human erythrocyte band 3 polymorphism (band 3 Memphis): characterization of the structural modification (Lys 56-->Glu) by protein chemistry methods.
1722314	Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis.
1885574	Palmitoylation of cysteine 69 from the COOH-terminal of band 3 protein in the human erythrocyte membrane. Acylation occurs in the middle of the consensus sequence of F--I-IICLAVL found in band 3 protein and G2 protein of Rift Valley fever virus.
1998697	Phosphorylation sites in human erythrocyte band 3 protein.
2594752	Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1).

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OMIM Diseases Associated

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OMIM ID	Disease Name
166900	Ovalocytosis, Southeast Asian
179800	Renal tubular acidosis, distal, autosomal dominant
185020	Cryohydrocytosis
611590	Renal tubular acidosis, distal, with hemolytic anemia
611590	Renal tubular acidosis, distal, with normal red cell morphology

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Protein Domains Associated

Showing 1 to 10 of 18 entries

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Domain Name	Domain ID	Source
ae	TIGR00834	TIGRFAMs
Anion_exchange	IPR001717	InterPro
Anion_exchange_1	IPR002977	InterPro
Anion_exchange_CS	IPR018241	InterPro
ANION_EXCHANGER_1	PS00219	PROSITE
ANION_EXCHANGER_2	PS00220	PROSITE
ANIONEXCHNGR	PR00165	PRINTS
ANIONEXHNGR1	PR01187	PRINTS
B3HU	A36218	PIR
Band3_cytoplasmic_dom	IPR013769	InterPro

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