Protein: P37231 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P37231 (Uniprot)	PPARG_HUMAN	PPARG	Peroxisome proliferator-activated receptor gamma	human	No

Protein Function

Uniprot: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisoma more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0034641	cellular nitrogen compound metabolic process	245, 789	4.22e-144	6.90e-18
GO:0007165	signal transduction	169	GO:0006725	cellular aromatic compound metabolic process	345	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
42	GO:0031325	positive regulation of cellular metabolic process
42	GO:0010604	positive regulation of macromolecule metabolic process
42	GO:0051173	positive regulation of nitrogen compound metabolic process
42	GO:0006355	regulation of transcription, DNA-templated
42	GO:0007165	signal transduction
165	GO:0006464	cellular protein modification process
165	GO:0070887	cellular response to chemical stimulus
165	GO:0031325	positive regulation of cellular metabolic process
165	GO:0010604	positive regulation of macromolecule metabolic process
165	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
42	GO:0005829	cytosol
42	GO:0005654	nucleoplasm
165	GO:0005829	cytosol
165	GO:0043232	intracellular non-membrane-bounded organelle
165	GO:0005654	nucleoplasm
169	GO:0005654	nucleoplasm
245	GO:0005634	nucleus
301	GO:0005829	cytosol
301	GO:0005634	nucleus
341	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0001890	placenta development	ISS
GO:0002674	negative regulation of acute inflammatory response	IEA
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0006629	lipid metabolic process	TAS
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA
GO:0007165	signal transduction	IDA
GO:0007186	G-protein coupled receptor signaling pathway	IEA
GO:0007507	heart development	IEA
GO:0007584	response to nutrient	TAS

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	ISS
GO:0043231	intracellular membrane-bounded organelle	IDA
GO:0043234	protein complex	IDA
GO:0048471	perinuclear region of cytoplasm	IEA
GO:0090575	RNA polymerase II transcription factor complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
BACD1_HUMAN	No
CAV1_HUMAN	No
CBP_HUMAN	No
CDK5_HUMAN	No
CHD8_HUMAN	No
CLUS_HUMAN	No
CSN5_HUMAN	No
EDF1_HUMAN	No
EP300_HUMAN	Yes: Q09472 (MoonDB)
FABPL_HUMAN	No

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Publications Associated

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PMID	Article Title
7787419	Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.
8702406	Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2.
8706692	A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs.
9065481	Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists.
9144532	Differential expression of PPAR gamma1 and gamma2 isoforms in human adipose tissue.
9356045	No coding mutations are detected in the peroxisome proliferator-activated receptor-gamma gene in Japanese patients with lipoatrophic diabetes.
9425261	Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR-gamma) gene in diabetic Caucasians: identification of a pro12ala PPAR-gamma-2 missense mutation.
9744270	Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
9753710	Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
9806549	A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

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OMIM Diseases Associated

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OMIM ID	Disease Name
137800	Glioma 1
601665	Obesity
604367	Lipodystrophy, familial partial, 3

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Protein Domains Associated

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Domain Name	Domain ID	Source
1Cnucl_rcpt	IPR003074	InterPro
HOLI	SM00430	SMART
Hormone_recep	PF00104	Pfam
JC4859	JC4859	PIR
NHR_like_dom_sf	IPR035500	InterPro
NR_LBD	PS51843	PROSITE
Nucl_hrmn_rcpt_lig-bd	IPR000536	InterPro
Nuclear_hrmn_rcpt	IPR001723	InterPro
NUCLEAR_REC_DBD_1	PS00031	PROSITE
NUCLEAR_REC_DBD_2	PS51030	PROSITE

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