Protein: P42566 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P42566 (Uniprot)	EPS15_HUMAN	EPS15	Epidermal growth factor receptor substrate 15	human	Yes

Protein Function

Uniprot: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). A more..

Dissimilar Functions Manual Curation

Function 1: Involved in cell growth regulation. EGFR phosphorylation. Acts as a clathrin adapter required for post-Golgi trafficking. Condition: cytoplasm or cell membrane localisation.

Function 2: Transcription regulation. Condition: nuclear localisation (import due to its N-terminal domain, export LMB sensitive with interaction with CRM1).

Publications (PMID): 11777906, 11425879, 19814798

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 11 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction
215	GO:0044267	cellular protein metabolic process
215	GO:0007167	enzyme linked receptor protein signaling pathway
215	GO:0010467	gene expression
215	GO:0016310	phosphorylation
215	GO:1902531	regulation of intracellular signal transduction
215	GO:0060255	regulation of macromolecule metabolic process
451	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
134	GO:0005829	cytosol
134	GO:0005634	nucleus
215	GO:0012505	endomembrane system
215	GO:0005886	plasma membrane
215	GO:0031982	vesicle
368	GO:0005829	cytosol
368	GO:0005634	nucleus
368	GO:0031982	vesicle
451	GO:0005829	cytosol
451	GO:0012505	endomembrane system

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001921	positive regulation of receptor recycling	IEA
GO:0006895	Golgi to endosome transport	IMP
GO:0007173	epidermal growth factor receptor signaling pathway	TAS
GO:0008283	cell proliferation	TAS
GO:0015031	protein transport	IEA
GO:0016050	vesicle organization	TAS
GO:0019065	receptor-mediated endocytosis of virus by host cell	IMP
GO:0032456	endocytic recycling	IC
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0042127	regulation of cell proliferation	IEA

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Cellular Components

Showing 1 to 10 of 11 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0005905	clathrin-coated pit	TAS
GO:0009925	basal plasma membrane	IEA
GO:0016020	membrane	IDA
GO:0016235	aggresome	IDA
GO:0016324	apical plasma membrane	IEA
GO:0030122	AP-2 adaptor complex	IEA
GO:0031901	early endosome membrane	IEA
GO:0043231	intracellular membrane-bounded organelle	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005886	plasma membrane	GO:0043231	intracellular membrane-bounded organelle	0.00e+00	3.79e-47

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABL1_HUMAN	Yes: P00519 (MoonDB)
CRK_HUMAN	Yes: P46108 (MoonDB)
EPN1_HUMAN	Yes: Q9Y6I3 (MoonDB)
FYN_HUMAN	Yes: P06241 (MoonDB)
GRB2_HUMAN	Yes: P62993 (MoonDB)
HGS_HUMAN	No
ITSN1_HUMAN	No
ITSN2_HUMAN	No
LAPM5_HUMAN	No
MDM2_HUMAN	Yes: Q00987 (MoonDB)

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Publications Associated

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PMID	Article Title
8134107	A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.
8183552	The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.
8662907	Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
9721102	Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.
9723620	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.
10757979	Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.
11062555	Molecular mechanism of NPF recognition by EH domains.
12551915	STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
16159959	Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
EF-hand-dom_pair	IPR011992	InterPro
EF-hand_4	PF12763	Pfam
EF_HAND_1	PS00018	PROSITE
EF_Hand_1_Ca_BS	IPR018247	InterPro
EF_HAND_2	PS50222	PROSITE
EF_hand_dom	IPR002048	InterPro
EFh	SM00054	SMART
EH	PS50031	PROSITE
EH	SM00027	SMART
EH_dom	IPR000261	InterPro

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