Protein: P47017 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P47017 (Uniprot)	LSM1_YEAST	LSM1	Sm-like protein LSm1	yeast	No

Protein Function

Uniprot: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends.

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0008104	protein localization	1184	GO:0044260	cellular macromolecule metabolic process	1188, 1250	7.50e-19	5.37e-13
GO:0044260	cellular macromolecule metabolic process	894, 1041, 1099, 1152	GO:0070727	cellular macromolecule localization	1184	2.61e-07	8.40e-04

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 17 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
894	GO:0016070	RNA metabolic process
894	GO:0010467	gene expression
934	GO:0016310	phosphorylation
964	GO:0006397	mRNA processing
964	GO:0000956	nuclear-transcribed mRNA catabolic process
964	GO:0022613	ribonucleoprotein complex biogenesis
1041	GO:0016070	RNA metabolic process
1041	GO:0010467	gene expression
1099	GO:0016070	RNA metabolic process
1099	GO:0010467	gene expression

Previous1 2Next

Cellular Components

Showing 1 to 10 of 13 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
894	GO:0044428	nuclear part
903	GO:0005634	nucleus
925	GO:0016021	integral component of membrane
964	GO:0000932	P-body
964	GO:0005634	nucleus
1041	GO:0005634	nucleus
1099	GO:0030529	intracellular ribonucleoprotein complex
1152	GO:0043232	intracellular non-membrane-bounded organelle
1152	GO:0031981	nuclear lumen
1184	GO:0005634	nucleus

Previous1 2Next

Protein GO Annotations

Biological Processes

Showing 1 to 3 of 3 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	IPI
GO:0006397	mRNA processing	IEA

Previous1Next

Cellular Components

Showing 1 to 5 of 5 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000932	P-body	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005845	mRNA cap binding complex	IPI
GO:1990726	Lsm1-7-Pat1 complex	IDA

Previous1Next

Dissimilar Cellular Components (PrOnto)

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005737	cytoplasm	5.14e-51	7.30e-86

Previous1Next

All Protein Interactions

Showing 1 to 10 of 40 entries

Search:

Interactor	Also a MoonDB EMF protein
ADT1_YEAST	No
AIR2_YEAST	No
ATC7_YEAST	No
BRO1_YEAST	No
CHK1_YEAST	No
CMS1_YEAST	No
DCE_YEAST	No
DHE4_YEAST	No
EI2BA_YEAST	No
FUN30_YEAST	No

Previous1 2 3 4Next

Publications Associated

Showing 1 to 10 of 12 entries

Search:

PMID	Article Title
8641269	Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
8948101	Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon.
9710590	Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant.
10747033	A Sm-like protein complex that participates in mRNA degradation.
10761922	Yeast Sm-like proteins function in mRNA decapping and decay.
10913177	The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p.
14562095	Global analysis of protein localization in budding yeast.
14562106	Global analysis of protein expression in yeast.
17322287	Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
24139796	Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover.

Previous1 2Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

Search:

Domain Name	Domain ID	Source
LSM	PF01423	Pfam
Lsm1	IPR034104	InterPro
LSm1	cd01728	CDD
LSM_dom_euk/arc	IPR001163	InterPro
LSM_dom_sf	IPR010920	InterPro
S56905	S56905	PIR
Sm	SM00651	SMART
SSF50182	SSF50182	SUPFAM

Previous1Next