Protein: P62258 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P62258 (Uniprot)	1433E_HUMAN	YWHAE	14-3-3 protein epsilon	human	No

Protein Function

Uniprot: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By simi more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0043170	macromolecule metabolic process	310	GO:0042886	amide transport	663	2.11e-04	2.73e-69

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1	GO:0035556	intracellular signal transduction
1	GO:0032268	regulation of cellular protein metabolic process
1	GO:0043067	regulation of programmed cell death
1	GO:0009966	regulation of signal transduction
2	GO:0044267	cellular protein metabolic process
2	GO:0010467	gene expression
2	GO:0006139	nucleobase-containing compound metabolic process
2	GO:0060255	regulation of macromolecule metabolic process
2	GO:0007165	signal transduction
3	GO:0022607	cellular component assembly

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1	GO:0005829	cytosol
1	GO:0005634	nucleus
2	GO:0005829	cytosol
2	GO:0005634	nucleus
3	GO:0044430	cytoskeletal part
3	GO:0005829	cytosol
3	GO:0005634	nucleus
4	GO:0005829	cytosol
4	GO:0005634	nucleus
6	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000086	G2/M transition of mitotic cell cycle	TAS
GO:0000165	MAPK cascade	IDA
GO:0001764	neuron migration	IEA
GO:0003064	regulation of heart rate by hormone	NAS
GO:0006605	protein targeting	IEA
GO:0010389	regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016032	viral process	IEA
GO:0021762	substantia nigra development	IEP
GO:0021766	hippocampus development	IEA
GO:0021987	cerebral cortex development	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IEA
GO:0005829	cytosol	TAS
GO:0005871	kinesin complex	IEA
GO:0005886	plasma membrane	IDA
GO:0005925	focal adhesion	IDA
GO:0016020	membrane	IDA
GO:0030424	axon	IEA
GO:0030659	cytoplasmic vesicle membrane	TAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0030659	cytoplasmic vesicle membrane	4.71e-30	7.28e-80
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433B_HUMAN	No
1433F_HUMAN	No
1433G_HUMAN	No
1433T_HUMAN	No
1433Z_HUMAN	Yes: P63104 (MoonDB)
ACD_HUMAN	Yes: Q96AP0 (MoonDB)
ANKH1_HUMAN	No
ARAF_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
BAD_HUMAN	No

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Publications Associated

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PMID	Article Title
2026444	Isolation and partial characterization of the structures of fibroblast activating factor-related proteins from U937 cells.
7644510	14-3-3 proteins associate with cdc25 phosphatases.
8684458	Function of 14-3-3 proteins.
8858348	14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.
10409742	Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
10644344	Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.
11427721	Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.
12042314	Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
12665801	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12917326	Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
14-3-3	IPR000308	InterPro
14-3-3	PF00244	Pfam
14-3-3	PIRSF000868	PIRSF
14-3-3_CS	IPR023409	InterPro
14-3-3_dom_sf	IPR036815	InterPro
14-3-3_domain	IPR023410	InterPro
1433_1	PS00796	PROSITE
1433_2	PS00797	PROSITE
1433ZETA	PR00305	PRINTS
14_3_3	SM00101	SMART

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