Protein: Q05080 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q05080 (Uniprot)	CYK2_YEAST	HOF1	Cytokinesis protein 2	yeast	No

Protein Function

Uniprot: Throughout most of the cell cycle it forms a double ring that coincides with the septins. After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Mediates cytoskeletal rearrangements required for cytokinesis. In conjunction with the medial actin ring exhibits contract more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0044260	cellular macromolecule metabolic process	1018	GO:0097435	supramolecular fiber organization	1177	6.22e-07	4.50e-41

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
932	GO:0016070	RNA metabolic process
932	GO:0010467	gene expression
1018	GO:0016070	RNA metabolic process
1018	GO:0010468	regulation of gene expression
1177	GO:0007015	actin filament organization
1177	GO:0022607	cellular component assembly
1177	GO:0044087	regulation of cellular component biogenesis
1177	GO:0033043	regulation of organelle organization

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
932	GO:0005634	nucleus
948	GO:0043232	intracellular non-membrane-bounded organelle
954	GO:0043232	intracellular non-membrane-bounded organelle
958	GO:0005935	cellular bud neck
980	GO:0005634	nucleus
1000	GO:0005634	nucleus
1018	GO:0043232	intracellular non-membrane-bounded organelle
1018	GO:0005634	nucleus
1165	GO:0016021	integral component of membrane
1177	GO:0005856	cytoskeleton

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000281	mitotic cytokinesis	IMP
GO:0000917	division septum assembly	IMP
GO:0090339	negative regulation of formin-nucleated actin cable assembly	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000142	cellular bud neck contractile ring	IDA
GO:0000144	cellular bud neck septin ring	IDA
GO:0005935	cellular bud neck	IDA
GO:0044697	HICS complex	IPI

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AGP2_YEAST	No
AIM3_YEAST	No
AIM44_YEAST	No
ALY2_YEAST	No
APP1_YEAST	No
ATC8_YEAST	No
ATG17_YEAST	No
BBC1_YEAST	Yes: P47068 (MoonDB)
BEM3_YEAST	No
BNI1_YEAST	No

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Publications Associated

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PMID	Article Title
9169872	The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
9864366	Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution.
14562106	Global analysis of protein expression in yeast.
18344988	Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.
18407956	A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19528296	Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
19779198	Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
24374639	The reference genome sequence of Saccharomyces cerevisiae: Then and now.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
AH/BAR_dom_sf	IPR027267	InterPro
F_BAR	IPR031160	InterPro
F_BAR	PS51741	PROSITE
FCH	PF00611	Pfam
FCH	SM00055	SMART
FCH_dom	IPR001060	InterPro
S53948	S53948	PIR
SH3	PS50002	PROSITE
SH3	SM00326	SMART
SH3-like_dom_sf	IPR036028	InterPro

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