Protein: Q8IXK0 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8IXK0 (Uniprot)	PHC2_HUMAN	PHC2	Polyhomeotic-like protein 2	human	No

Protein Function

Uniprot: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	682	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 9 of 9 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
682	GO:0034645	cellular macromolecule biosynthetic process
682	GO:0006464	cellular protein modification process
682	GO:0035556	intracellular signal transduction
682	GO:0090304	nucleic acid metabolic process
682	GO:0010468	regulation of gene expression
682	GO:0019219	regulation of nucleobase-containing compound metabolic process

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Cellular Components

Showing 1 to 5 of 5 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
84	GO:0005634	nucleus
125	GO:0005829	cytosol
125	GO:0005634	nucleus
567	GO:0005634	nucleus
682	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007275	multicellular organism development	IEA
GO:0007283	spermatogenesis	IEA

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000792	heterochromatin	IEA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0031519	PcG protein complex	IDA
GO:0035102	PRC1 complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 71 entries

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Interactor	Also a MoonDB EMF protein
AAPK1_HUMAN	No
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
AEN_HUMAN	No
AFG32_HUMAN	No
AP1M1_HUMAN	No
BMI1_HUMAN	No
BSDC1_HUMAN	No
BYST_HUMAN	No
CA109_HUMAN	No
CARD9_HUMAN	No

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Publications Associated

Showing 1 to 10 of 18 entries

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PMID	Article Title
9121482	Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
9199346	RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
10976766	A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.
12167701	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
12384788	Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15094067	P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.
15386022	Role of histone H2A ubiquitination in Polycomb silencing.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16710414	The DNA sequence and biological annotation of human chromosome 1.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

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Domain Name	Domain ID	Source
SAM	IPR001660	InterPro
SAM	SM00454	SMART
SAM/pointed_sf	IPR013761	InterPro
SAM_1	PF00536	Pfam
SAM_DOMAIN	PS50105	PROSITE
SSF47769	SSF47769	SUPFAM
ZF_FCS	PS51024	PROSITE
Znf_FCS	IPR012313	InterPro

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