Protein: Q9C0C9 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9C0C9 (Uniprot)	UBE2O_HUMAN	UBE2O	(E3-independent) E2 ubiquitin-conjugating enzyme	human	No

Protein Function

Uniprot: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	53	GO:0007165	signal transduction	831	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 17 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
238	GO:0060255	regulation of macromolecule metabolic process
656	GO:0016070	RNA metabolic process
656	GO:0034645	cellular macromolecule biosynthetic process
656	GO:0044271	cellular nitrogen compound biosynthetic process
656	GO:0010467	gene expression
656	GO:0060255	regulation of macromolecule metabolic process
780	GO:0006355	regulation of transcription, DNA-templated

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
238	GO:0005829	cytosol
238	GO:0005634	nucleus
656	GO:0043232	intracellular non-membrane-bounded organelle
656	GO:0005634	nucleus
780	GO:0005654	nucleoplasm
831	GO:0042995	cell projection
831	GO:0005829	cytosol
831	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 4 of 4 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006513	protein monoubiquitination	IDA
GO:0030513	positive regulation of BMP signaling pathway	IDA
GO:0042147	retrograde transport, endosome to Golgi	IMP
GO:0070534	protein K63-linked ubiquitination	IMP

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IEA
GO:0016604	nuclear body	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 21 entries

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Interactor	Also a MoonDB EMF protein
CHD1L_HUMAN	No
DP13A_HUMAN	Yes: Q9UKG1 (MoonDB)
GBRL2_HUMAN	Yes: P60520 (MoonDB)
LCA5_HUMAN	No
MUC18_HUMAN	No
PA1B3_HUMAN	No
RL12_HUMAN	No
RL29_HUMAN	No
RL40_HUMAN	No
RNF10_HUMAN	No

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Publications Associated

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PMID	Article Title
11214970	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
11311559	Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16625196	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17974005	The full-ORF clone resource of the German cDNA consortium.
18220336	Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18669648	A quantitative atlas of mitotic phosphorylation.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
SSF54495	SSF54495	SUPFAM
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UQ_con	PF00179	Pfam

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