Protein: Q9UBC2 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9UBC2 (Uniprot)	EP15R_HUMAN	EPS15L1	Epidermal growth factor receptor substrate 15-like 1	human	Yes

Protein Function

Uniprot: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Dissimilar Functions Manual Curation

Function 1: Involved in cell growth regulation. EGFR phosphorylation. Acts as a clathrin adapter required for post-Golgi trafficking. Condition: cytoplasm or cell membrane localisation.

Function 2: Transcription regulation. Condition: nuclear localisation (import due to its N-terminal domain, export LMB sensitive with interaction with CRM1).

Publications (PMID): 11777906, 11425879, 19814798

MoonDB Network Modules

Biological Processes

Showing 1 to 2 of 2 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
796	GO:0034645	cellular macromolecule biosynthetic process
796	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
796	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006897	endocytosis	IEA
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0061024	membrane organization	TAS

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0016020	membrane	IDA
GO:0030132	clathrin coat of coated pit	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236

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All Protein Interactions

Showing 1 to 8 of 8 entries

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Interactor	Also a MoonDB EMF protein
GBG5_HUMAN	No
ITSN1_HUMAN	No
ITSN2_HUMAN	No
LRRC7_HUMAN	No
NDC80_HUMAN	No
STON2_HUMAN	No
TPC2A_HUMAN	No
UBQL1_HUMAN	No

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Publications Associated

Showing 1 to 10 of 21 entries

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PMID	Article Title
9407958	eps15 and eps15R are essential components of the endocytic pathway.
9853615	Selection system for genes encoding nuclear-targeted proteins.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824	The DNA sequence and biology of human chromosome 19.
15144186	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16159959	Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.
16964243	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
18669648	A quantitative atlas of mitotic phosphorylation.
19262564	SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
EF-hand-dom_pair	IPR011992	InterPro
EF-hand_4	PF12763	Pfam
EF_HAND_1	PS00018	PROSITE
EF_Hand_1_Ca_BS	IPR018247	InterPro
EF_HAND_2	PS50222	PROSITE
EF_hand_dom	IPR002048	InterPro
EFh	SM00054	SMART
EH	PS50031	PROSITE
EH	SM00027	SMART
EH_dom	IPR000261	InterPro

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