Protein: Q9UHD9 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9UHD9 (Uniprot)	UBQL2_HUMAN	UBQLN2	Ubiquilin-2	human	No

Protein Function

Uniprot: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degrada more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	56, 134, 197, 204, 379, 414, 578, 594, 643	GO:0016070	RNA metabolic process	715	5.15e-08	2.82e-13
GO:0036211	protein modification process	199, 258, 358, 362	GO:0016070	RNA metabolic process	715	5.81e-04	8.44e-05

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
22	GO:0019538	protein metabolic process
22	GO:0007165	signal transduction
54	GO:0010467	gene expression
54	GO:0006139	nucleobase-containing compound metabolic process
54	GO:0060255	regulation of macromolecule metabolic process
56	GO:0044267	cellular protein metabolic process
56	GO:0060255	regulation of macromolecule metabolic process
64	GO:0016070	RNA metabolic process
64	GO:0010467	gene expression
64	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
14	GO:0031410	cytoplasmic vesicle
14	GO:0005829	cytosol
14	GO:0005783	endoplasmic reticulum
22	GO:0005576	extracellular region
22	GO:0005886	plasma membrane
22	GO:0031982	vesicle
54	GO:0070013	intracellular organelle lumen
54	GO:0005634	nucleus
56	GO:0005829	cytosol
60	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006914	autophagy	IEA
GO:0016241	regulation of macroautophagy	IMP
GO:0030433	ubiquitin-dependent ERAD pathway	IMP
GO:1900186	negative regulation of clathrin-dependent endocytosis	IMP
GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process	IMP
GO:1904021	negative regulation of G-protein coupled receptor internalization	IMP
GO:2000785	regulation of autophagosome assembly	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IDA
GO:0005776	autophagosome	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0031410	cytoplasmic vesicle	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0031410	cytoplasmic vesicle	9.49e-36	4.91e-56

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
5NT3A_HUMAN	No
7B2_HUMAN	No
A0A024R8L2_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
ADRM1_HUMAN	No
AGR2_HUMAN	No
AGR3_HUMAN	No
AMBN_HUMAN	No
ANF_HUMAN	No
ANR33_HUMAN	No

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Publications Associated

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PMID	Article Title
9853615	Selection system for genes encoding nuclear-targeted proteins.
10675567	A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.
10983987	The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.
11827521	Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15772651	The DNA sequence of the human X chromosome.
16813565	Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.
17098253	Ubiquitin receptor proteins hHR23a and hPLIC2 interact.
17974005	The full-ORF clone resource of the German cDNA consortium.
18199683	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

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OMIM Diseases Associated

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OMIM ID	Disease Name
300857	Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia

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Protein Domains Associated

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Domain Name	Domain ID	Source
ARM-type_fold	IPR016024	InterPro
PTHR10677	PTHR10677	PANTHER
PTHR10677:SF5	PTHR10677:SF5	PANTHER
SSF46934	SSF46934	SUPFAM
SSF48371	SSF48371	SUPFAM
SSF54236	SSF54236	SUPFAM
STI1	SM00727	SMART
STI1_HS-bd	IPR006636	InterPro
UBA	IPR015940	InterPro
UBA	PF00627	Pfam

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