Protein: P04406 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P04406 (Uniprot)	G3P_HUMAN	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	human	Yes

Protein Function

Uniprot: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activi more..

Dissimilar Functions Manual Curation

Function 1: Has glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities. Condition: monomeric form.

Function 2: Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Condition: tetrameric form.

Publications (PMID): 1924305, 15877277

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 24 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
51	GO:0060255	regulation of macromolecule metabolic process
116	GO:0019538	protein metabolic process
116	GO:0060255	regulation of macromolecule metabolic process
214	GO:0044267	cellular protein metabolic process
214	GO:0006355	regulation of transcription, DNA-templated
237	GO:0022607	cellular component assembly
237	GO:0034645	cellular macromolecule biosynthetic process
237	GO:0044271	cellular nitrogen compound biosynthetic process
237	GO:0006464	cellular protein modification process
237	GO:0051649	establishment of localization in cell

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
51	GO:0005634	nucleus
116	GO:0005829	cytosol
116	GO:0070013	intracellular organelle lumen
116	GO:0005634	nucleus
214	GO:0044428	nuclear part
237	GO:0005829	cytosol
237	GO:0012505	endomembrane system
237	GO:0005615	extracellular space
237	GO:0043232	intracellular non-membrane-bounded organelle
237	GO:0070013	intracellular organelle lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000226	microtubule cytoskeleton organization	ISS
GO:0006094	gluconeogenesis	TAS
GO:0010951	negative regulation of endopeptidase activity	IDA
GO:0016241	regulation of macroautophagy	TAS
GO:0017148	negative regulation of translation	IDA
GO:0031640	killing of cells of other organism	IDA
GO:0035606	peptidyl-cysteine S-trans-nitrosylation	ISS
GO:0050715	positive regulation of cytokine secretion	IDA
GO:0050821	protein stabilization	ISS
GO:0050832	defense response to fungus	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005811	lipid droplet	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0015630	microtubule cytoskeleton	ISS
GO:0016020	membrane	IDA
GO:0030529	intracellular ribonucleoprotein complex	IDA
GO:0031012	extracellular matrix	IDA
GO:0031965	nuclear membrane	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 9 of 9 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0031012	extracellular matrix	1.58e-13	4.18e-03
GO:0005634	nucleus	GO:0031982	vesicle	1.94e-54	3.27e-93
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005829	cytosol	GO:0031012	extracellular matrix	4.46e-06	5.18e-08
GO:0005886	plasma membrane	GO:0015630	microtubule cytoskeleton	4.17e-10	2.15e-03
GO:0005886	plasma membrane	GO:0030529	intracellular ribonucleoprotein complex	1.50e-65	9.46e-34
GO:0005886	plasma membrane	GO:0043231	intracellular membrane-bounded organelle	0.00e+00	3.79e-47

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433E_HUMAN	Yes: P62258 (MoonDB)
AATM_HUMAN	No
ACD_HUMAN	Yes: Q96AP0 (MoonDB)
ACTB_HUMAN	No
ACTC_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ANXA1_HUMAN	No
ANXA7_HUMAN	No
ARL15_HUMAN	No
ATN1_HUMAN	No

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Publications Associated

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PMID	Article Title
957435	Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase.
1193541	The covalent structure of glyceraldehyde-phosphate dehydrogenase from human muscles. Isolation and amino acid sequences of peptides from tryptic digest.
1924305	A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase.
2987855	Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene.
3027061	Identification of the 37-kDa protein displaying a variable interaction with the erythroid cell membrane as glyceraldehyde-3-phosphate dehydrogenase.
3170585	Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene.
3664468	Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers.
6096136	The glyceraldehyde 3 phosphate dehydrogenase gene family: structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse.
6096821	The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species.
7030790	The complete amino acid sequence of human muscle glyceraldehyde 3-phosphate dehydrogenase.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 16 entries

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Domain Name	Domain ID	Source
DEHUG3	A31988	PIR
G3PDHDRGNASE	PR00078	PRINTS
GAP_DH	PIRSF000149	PIRSF
GAPDH	PS00071	PROSITE
GAPDH-I	TIGR01534	TIGRFAMs
GlycerAld/Erythrose_P_DH	IPR020831	InterPro
GlycerAld_3-P_DH_AS	IPR020830	InterPro
GlycerAld_3-P_DH_cat	IPR020829	InterPro
GlycerAld_3-P_DH_NAD(P)-bd	IPR020828	InterPro
Glyceraldehyde-3-P_DH_1	IPR006424	InterPro

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