Protein: P19971 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P19971 (Uniprot)	TYPH_HUMAN	TYMP	Thymidine phosphorylase	human	Yes

Protein Function

Uniprot: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and ene more..

Dissimilar Functions Manual Curation

Function 1: Thymidine phosphorylase. Condition: cytoplasmic localisation.

Function 2: Platelet-derived endothelial cell growth factor. Condition: extracellular fluid.

Publications (PMID): 1570012

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

No results found.

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 12 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000002	mitochondrial genome maintenance	IMP
GO:0001525	angiogenesis	IEA
GO:0006206	pyrimidine nucleobase metabolic process	IEA
GO:0006213	pyrimidine nucleoside metabolic process	IMP
GO:0006935	chemotaxis	IEA
GO:0010469	regulation of receptor activity	IEA
GO:0030154	cell differentiation	IEA
GO:0031641	regulation of myelination	IMP
GO:0043097	pyrimidine nucleoside salvage	TAS
GO:0046135	pyrimidine nucleoside catabolic process	TAS

Previous1 2Next

Cellular Components

Showing 1 to 1 of 1 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS

Previous1Next

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 1 of 1 entries

Search:

Interactor	Also a MoonDB EMF protein
ZMY12_HUMAN	No

Previous1Next

Publications Associated

Showing 1 to 10 of 14 entries

Search:

PMID	Article Title
1400349	Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.
1570012	Angiogenic factor.
1580101	Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae.
1590793	Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
2467210	Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
9924029	Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.
10591208	The DNA sequence of human chromosome 22.
12177387	Phenotypic variability in a Spanish family with MNGIE.
14725767	Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Previous1 2Next

OMIM Diseases Associated

Showing 1 to 1 of 1 entries

Search:

OMIM ID	Disease Name
603041	Mitochondrial DNA depletion syndrome 1, MNGIE type

Previous1Next

Protein Domains Associated

Showing 1 to 10 of 21 entries

Search:

Domain Name	Domain ID	Source
Glycos_trans_3N	PF02885	Pfam
Glycos_transf_3	PF00591	Pfam
Glycosyl_Trfase_fam3	IPR000312	InterPro
Glycosyl_Trfase_fam3_N_dom	IPR017459	InterPro
Glycosyl_Trfase_fam3_N_dom)sf	IPR036320	InterPro
Nuc_phospho_transferase	IPR035902	InterPro
PTHR10515	PTHR10515	PANTHER
PYNP-like_C_sf	IPR036566	InterPro
PYNP_C	IPR013102	InterPro
PYNP_C	PF07831	Pfam

Previous1 2 3Next