Protein: P21333 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P21333 (Uniprot)	FLNA_HUMAN	FLNA	Filamin-A	human	No

Protein Function

Uniprot: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricu more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35	5.53e-55	9.57e-64

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
306	GO:0070062	extracellular exosome
479	GO:0070013	intracellular organelle lumen
479	GO:0044428	nuclear part
498	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002576	platelet degranulation	TAS
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IMP
GO:0016479	negative regulation of transcription from RNA polymerase I promoter	IDA
GO:0021943	formation of radial glial scaffolds	IEA
GO:0021987	cerebral cortex development	IEA
GO:0030168	platelet activation	TAS
GO:0030334	regulation of cell migration	IDA
GO:0031532	actin cytoskeleton reorganization	IDA
GO:0034329	cell junction assembly	TAS
GO:0034394	protein localization to cell surface	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005634	nucleus	IDA
GO:0005730	nucleolus	IMP
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0005911	cell-cell junction	IDA
GO:0005925	focal adhesion	IDA
GO:0015629	actin cytoskeleton	IC
GO:0016020	membrane	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005576	extracellular region	GO:0005730	nucleolus	6.04e-15	4.85e-05
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0031012	extracellular matrix	1.58e-13	4.18e-03
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005730	nucleolus	GO:0005886	plasma membrane	7.70e-47	3.09e-07
GO:0005730	nucleolus	GO:0016020	membrane	8.89e-46	1.83e-10
GO:0005829	cytosol	GO:0031012	extracellular matrix	4.46e-06	5.18e-08

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABL1_HUMAN	Yes: P00519 (MoonDB)
ANDR_HUMAN	Yes: P10275 (MoonDB)
APC_HUMAN	No
ATL4_HUMAN	No
BRCA2_HUMAN	No
CASR_HUMAN	No
CCNB2_HUMAN	No
CMIP_HUMAN	No
CRK_HUMAN	Yes: P46108 (MoonDB)
CRTP1_HUMAN	No

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Publications Associated

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PMID	Article Title
2248958	Purification of human smooth muscle filamin and characterization of structural domains and functional sites.
2391361	Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.
7689010	Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7.
8088819	The exon-intron organization of the human X-linked gene (FLN1) encoding actin-binding protein 280.
8733135	Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.
9437013	Interaction of presenilins with the filamin family of actin-binding proteins.
11102480	Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
11153914	Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.
11252955	Filamins as integrators of cell mechanics and signalling.
11336782	Structural and functional aspects of filamins.

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OMIM Diseases Associated

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OMIM ID	Disease Name
300048	Congenital short bowel syndrome, X-linked
300048	Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked
300049	Periventricular nodular heterotopia 1
300244	Terminal osseous dysplasia
300321	FG syndrome 2

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Protein Domains Associated

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Domain Name	Domain ID	Source
A37098	A37098	PIR
ACTININ_1	PS00019	PROSITE
ACTININ_2	PS00020	PROSITE
Actinin_actin-bd_CS	IPR001589	InterPro
Calponin-like_dom_sf	IPR036872	InterPro
CH	PF00307	Pfam
CH	PS50021	PROSITE
CH	SM00033	SMART
CH	cd00014	CDD
CH-domain	IPR001715	InterPro

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