Protein: P45973 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P45973 (Uniprot)	CBX5_HUMAN	CBX5	Chromobox protein homolog 5	human	No

Protein Function

Uniprot: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to more..

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	545	GO:0016070	RNA metabolic process	689	5.15e-08	2.82e-13
GO:0036211	protein modification process	425	GO:0016070	RNA metabolic process	689	5.81e-04	8.44e-05

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 11 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
425	GO:0006464	cellular protein modification process
461	GO:0034645	cellular macromolecule biosynthetic process
461	GO:0090304	nucleic acid metabolic process
461	GO:0034654	nucleobase-containing compound biosynthetic process
545	GO:0044267	cellular protein metabolic process
545	GO:0006139	nucleobase-containing compound metabolic process
559	GO:0006355	regulation of transcription, DNA-templated
689	GO:0006396	RNA processing
689	GO:0051252	regulation of RNA metabolic process
689	GO:0010468	regulation of gene expression

Previous1 2Next

Cellular Components

Showing 1 to 10 of 10 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
425	GO:0005634	nucleus
461	GO:0043232	intracellular non-membrane-bounded organelle
461	GO:0005634	nucleus
545	GO:0005829	cytosol
545	GO:0005634	nucleus
545	GO:0031982	vesicle
559	GO:0031981	nuclear lumen
689	GO:0005654	nucleoplasm
732	GO:0043232	intracellular non-membrane-bounded organelle
732	GO:0031981	nuclear lumen

Previous1Next

Protein GO Annotations

Biological Processes

Showing 1 to 5 of 5 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0007596	blood coagulation	TAS
GO:0016032	viral process	IEA
GO:0045892	negative regulation of transcription, DNA-templated	IMP
GO:0070317	negative regulation of G0 to G1 transition	TAS

Previous1Next

Cellular Components

Showing 1 to 10 of 16 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000118	histone deacetylase complex	ISS
GO:0000776	kinetochore	IEA
GO:0000784	nuclear chromosome, telomeric region	IDA
GO:0005634	nucleus	IDA
GO:0005635	nuclear envelope	TAS
GO:0005654	nucleoplasm	TAS
GO:0005720	nuclear heterochromatin	TAS
GO:0005721	pericentric heterochromatin	ISS
GO:0005730	nucleolus	IDA
GO:0010369	chromocenter	IEA

Previous1 2Next

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 37 entries

Search:

Interactor	Also a MoonDB EMF protein
AMPL_HUMAN	No
ARL5A_HUMAN	No
BAP1_HUMAN	No
CAF1B_HUMAN	No
CRCM_HUMAN	No
DNM3A_HUMAN	No
ELOA2_HUMAN	No
ELOC_HUMAN	No
ENOA_HUMAN	Yes: P06733 (MoonDB)
FSHR_HUMAN	No

Previous1 2 3 4Next

Publications Associated

Showing 1 to 10 of 38 entries

Search:

PMID	Article Title
8505380	Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity.
8663349	Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.
9169472	Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.
10460410	Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.
11242053	Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
11313457	Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15502821	A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.
15864296	Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles.

Previous1 2 3 4Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 16 entries

Search:

Domain Name	Domain ID	Source
Chromo	PF00385	Pfam
CHROMO	SM00298	SMART
CHROMO	cd00024	CDD
Chromo-like_dom_sf	IPR016197	InterPro
Chromo/chromo_shadow_dom	IPR000953	InterPro
CHROMO_1	PS00598	PROSITE
CHROMO_2	PS50013	PROSITE
Chromo_dom_subgr	IPR017984	InterPro
Chromo_domain	IPR023780	InterPro
Chromo_shadow	PF01393	Pfam

Previous1 2Next