Protein: P60520 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P60520 (Uniprot)	GBRL2_HUMAN	GABARAPL2	Gamma-aminobutyric acid receptor-associated protein-like 2	human	No

Protein Function

Uniprot: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0033036	macromolecule localization	517	GO:0009059	macromolecule biosynthetic process	62	2.32e-08	6.09e-30

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MoonDB Network Modules

Biological Processes

Showing 1 to 8 of 8 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
62	GO:0034645	cellular macromolecule biosynthetic process
62	GO:0090304	nucleic acid metabolic process
62	GO:1901362	organic cyclic compound biosynthetic process
62	GO:0060255	regulation of macromolecule metabolic process
404	GO:0044267	cellular protein metabolic process
404	GO:0007165	signal transduction
517	GO:0008104	protein localization
517	GO:0019538	protein metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
62	GO:0005829	cytosol
62	GO:0005634	nucleus
404	GO:0005829	cytosol
404	GO:0012505	endomembrane system
404	GO:0031982	vesicle
517	GO:0005829	cytosol
517	GO:0012505	endomembrane system
517	GO:0031982	vesicle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000045	autophagosome assembly	IBA
GO:0000422	autophagy of mitochondrion	IBA
GO:0006891	intra-Golgi vesicle-mediated transport	ISS
GO:0006914	autophagy	NAS
GO:0006995	cellular response to nitrogen starvation	IBA
GO:0015031	protein transport	IEA
GO:0016236	macroautophagy	TAS
GO:0032781	positive regulation of ATPase activity	ISS
GO:0097352	autophagosome maturation	TAS
GO:1901799	negative regulation of proteasomal protein catabolic process	IMP

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Cellular Components

Showing 1 to 8 of 8 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000139	Golgi membrane	IDA
GO:0000421	autophagosome membrane	TAS
GO:0005622	intracellular	IDA
GO:0005737	cytoplasm	IDA
GO:0005776	autophagosome	IDA
GO:0005794	Golgi apparatus	ISS
GO:0005829	cytosol	TAS
GO:0031410	cytoplasmic vesicle	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 59 entries

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Interactor	Also a MoonDB EMF protein
1433Z_HUMAN	Yes: P63104 (MoonDB)
AAMP_HUMAN	No
AHNK2_HUMAN	No
ARFG1_HUMAN	No
ATG13_HUMAN	No
ATG4B_HUMAN	No
ATRAP_HUMAN	No
B2L13_HUMAN	No
BNI3L_HUMAN	No
BSDC1_HUMAN	No

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Publications Associated

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PMID	Article Title
11096062	The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
11146101	Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.
11414770	Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.
11825910	Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
12507496	GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15169837	LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17525332	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17580304	p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 6 of 6 entries

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Domain Name	Domain ID	Source
Atg8	PF02991	Pfam
Atg8-like	IPR004241	InterPro
GABARAP	cd01611	CDD
PTHR10969	PTHR10969	PANTHER
SSF54236	SSF54236	SUPFAM
Ubiquitin-like_domsf	IPR029071	InterPro

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