Protein: P63279 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P63279 (Uniprot)	UBC9_HUMAN	UBE2I	SUMO-conjugating enzyme UBC9	human	No

Protein Function

Uniprot: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. more..

MoonDB Dissimilar Functions

Showing 1 to 4 of 4 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	4, 169, 609	GO:0034641	cellular nitrogen compound metabolic process	504, 810	4.22e-144	6.90e-18
GO:0007165	signal transduction	4, 169, 609	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	294	4.83e-02	1.79e-71
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	192, 270, 286, 384, 471	6.37e-04	1.88e-40
GO:0019538	protein metabolic process	197, 234	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	294	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 253 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
4	GO:0035556	intracellular signal transduction
4	GO:0031399	regulation of protein modification process
4	GO:0009966	regulation of signal transduction
7	GO:0031324	negative regulation of cellular metabolic process
7	GO:0010605	negative regulation of macromolecule metabolic process
7	GO:0051172	negative regulation of nitrogen compound metabolic process
7	GO:0010604	positive regulation of macromolecule metabolic process
7	GO:0006357	regulation of transcription from RNA polymerase II promoter
17	GO:0006355	regulation of transcription, DNA-templated
51	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
4	GO:0005829	cytosol
4	GO:0005634	nucleus
7	GO:0005654	nucleoplasm
17	GO:0005829	cytosol
17	GO:0005654	nucleoplasm
51	GO:0005634	nucleus
54	GO:0070013	intracellular organelle lumen
54	GO:0005634	nucleus
99	GO:0005654	nucleoplasm
107	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 17 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS
GO:0006464	cellular protein modification process	TAS
GO:0006511	ubiquitin-dependent protein catabolic process	TAS
GO:0007049	cell cycle	IEA
GO:0007059	chromosome segregation	IEA
GO:0010469	regulation of receptor activity	IEA
GO:0016032	viral process	IEA
GO:0016567	protein ubiquitination	IEA
GO:0016925	protein sumoylation	TAS
GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway	IEA

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Cellular Components

Showing 1 to 10 of 12 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000795	synaptonemal complex	TAS
GO:0001650	fibrillar center	IEA
GO:0005634	nucleus	IDA
GO:0005635	nuclear envelope	TAS
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0016605	PML body	IDA
GO:0030425	dendrite	IEA
GO:0045202	synapse	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 3 of 3 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0045202	synapse	1.10e-08	8.94e-15
GO:0005654	nucleoplasm	GO:0045202	synapse	3.30e-10	4.22e-25
GO:0045202	synapse	GO:1990234	transferase complex	7.78e-03	4.87e-24

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All Protein Interactions

Showing 1 to 10 of 227 entries

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Interactor	Also a MoonDB EMF protein
AAPK2_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
AP2A_HUMAN	No
AP2B_HUMAN	No
AP2C_HUMAN	No
APEX1_HUMAN	No
ARIP4_HUMAN	No
ASF1B_HUMAN	No
ATF2_HUMAN	No
ATP8_HUMAN	No

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Publications Associated

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PMID	Article Title
8565643	Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle.
8610150	Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.
8668125	Two-hybrid interaction of a human UBC9 homolog with centromere proteins of Saccharomyces cerevisiae.
8668529	Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9.
8798754	Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9.
8824223	mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect.
9067428	Assignment of the gene for a ubiquitin-conjugating enzyme (UBE2I) to human chromosome band 16p13.3 by in situ hybridization.
9197546	Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9.
9261152	Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.
9333025	Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
JC6056	JC6056	PIR
PTHR43927	PTHR43927	PANTHER
SSF54495	SSF54495	SUPFAM
Ubc9	IPR027230	InterPro
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro

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