Protein: P67870 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P67870 (Uniprot)	CSK2B_HUMAN	CSNK2B	Casein kinase II subunit beta	human	No

Protein Function

Uniprot: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	27, 463	GO:0007165	signal transduction	534	1.10e-111	5.07e-25
GO:0007165	signal transduction	534	GO:0016070	RNA metabolic process	689	3.11e-78	2.75e-26
GO:0019538	protein metabolic process	578	GO:0016070	RNA metabolic process	689	5.15e-08	2.82e-13
GO:0036211	protein modification process	25, 26, 28	GO:0016070	RNA metabolic process	689	5.81e-04	8.44e-05

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
24	GO:0016070	RNA metabolic process
24	GO:0006464	cellular protein modification process
24	GO:0034654	nucleobase-containing compound biosynthetic process
24	GO:0006796	phosphate-containing compound metabolic process
24	GO:0031325	positive regulation of cellular metabolic process
24	GO:0010604	positive regulation of macromolecule metabolic process
24	GO:0051173	positive regulation of nitrogen compound metabolic process
24	GO:2000112	regulation of cellular macromolecule biosynthetic process
24	GO:0010468	regulation of gene expression
24	GO:0019219	regulation of nucleobase-containing compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
24	GO:0005829	cytosol
24	GO:0005654	nucleoplasm
25	GO:0005829	cytosol
25	GO:0005634	nucleus
26	GO:0005654	nucleoplasm
27	GO:0031981	nuclear lumen
28	GO:0005829	cytosol
28	GO:0043232	intracellular non-membrane-bounded organelle
28	GO:0005654	nucleoplasm
39	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 19 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006457	protein folding	TAS
GO:0006656	phosphatidylcholine biosynthetic process	TAS
GO:0007165	signal transduction	TAS
GO:0008285	negative regulation of cell proliferation	TAS
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IDA
GO:0016055	Wnt signaling pathway	IEA
GO:0016236	macroautophagy	TAS
GO:0018107	peptidyl-threonine phosphorylation	IDA
GO:0032927	positive regulation of activin receptor signaling pathway	IMP
GO:0033211	adiponectin-activated signaling pathway	IDA

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Cellular Components

Showing 1 to 10 of 14 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000785	chromatin	IEA
GO:0005576	extracellular region	TAS
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0005929	cilium	IEA
GO:0005956	protein kinase CK2 complex	NAS
GO:0016363	nuclear matrix	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 10 of 10 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000785	chromatin	GO:0005576	extracellular region	4.68e-06	8.78e-112
GO:0000785	chromatin	GO:0005737	cytoplasm	2.75e-08	6.83e-23
GO:0000785	chromatin	GO:0005886	plasma membrane	3.25e-35	5.24e-112
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005576	extracellular region	GO:0005654	nucleoplasm	6.62e-72	7.68e-98
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005654	nucleoplasm	GO:0005929	cilium	1.92e-09	0.00e+00
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
2A5D_HUMAN	No
2A5E_HUMAN	No
2AAA_HUMAN	No
2AAB_HUMAN	No
AAKB2_HUMAN	No
ABHD4_HUMAN	No
ACHA4_HUMAN	No
ACL6B_HUMAN	No
ACTB_HUMAN	No
ACTY_HUMAN	No

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Publications Associated

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PMID	Article Title
1694965	Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells.
1856204	Structure of the gene encoding human casein kinase II subunit beta.
2300566	Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.
2513884	Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.
2666134	Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta.
10357806	Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.
11239457	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
11298324	Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.
11574463	Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
11964394	Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 10 entries

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Domain Name	Domain ID	Source
A39459	A39459	PIR
Casein_kin_II_reg-sub_N	IPR016149	InterPro
Casein_kinase_II_beta_like	IPR035991	InterPro
Casein_kinase_II_reg-sub	IPR000704	InterPro
CASNKINASEII	PR00472	PRINTS
CK2_BETA	PS01101	PROSITE
CK_II_beta	PF01214	Pfam
CK_II_beta	SM01085	SMART
PTHR11740	PTHR11740	PANTHER
SSF57798	SSF57798	SUPFAM

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