Protein: Q9BYE9 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9BYE9 (Uniprot)	CDHR2_HUMAN	CDHR2	Cadherin-related family member 2	human	No

Protein Function

Uniprot: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic pr more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0036211	protein modification process	668	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	669	2.53e-05	1.12e-11

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MoonDB Network Modules

Biological Processes

Showing 1 to 5 of 5 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
668	GO:0006464	cellular protein modification process
668	GO:0006796	phosphate-containing compound metabolic process
669	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
669	GO:0090675	intermicrovillar adhesion
669	GO:0032532	regulation of microvillus length

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Cellular Components

Showing 1 to 5 of 5 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
669	GO:0016324	apical plasma membrane
669	GO:0031526	brush border membrane
669	GO:0070062	extracellular exosome
669	GO:0031528	microvillus membrane
669	GO:0044214	spanning component of plasma membrane

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0030855	epithelial cell differentiation	IDA
GO:0032532	regulation of microvillus length	IMP
GO:0044331	cell-cell adhesion mediated by cadherin	IDA
GO:0060243	negative regulation of cell growth involved in contact inhibition	IDA
GO:0090675	intermicrovillar adhesion	IMP

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005903	brush border	IDA
GO:0016324	apical plasma membrane	IDA
GO:0030054	cell junction	IEA
GO:0031526	brush border membrane	IDA
GO:0031528	microvillus membrane	IDA
GO:0044214	spanning component of plasma membrane	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
CDHR5_HUMAN	No
MAST2_HUMAN	No

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Publications Associated

Showing 1 to 10 of 10 entries

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PMID	Article Title
12117771	Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15372022	The DNA sequence and comparative analysis of human chromosome 5.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15534908	Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma.
18987736	DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
24275569	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24725409	Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.
26812017	Mechanistic basis of organization of the Harmonin/USH1C-mediated brush border microvilli tip-link complex.
26812018	ANKS4B is essential for intermicrovillar adhesion complex formation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
CA	SM00112	SMART
Cadherin	IPR002126	InterPro
Cadherin	PF00028	Pfam
CADHERIN	PR00205	PRINTS
Cadherin-like	IPR015919	InterPro
CADHERIN_1	PS00232	PROSITE
CADHERIN_2	PS50268	PROSITE
Cadherin_CS	IPR020894	InterPro
CDHR2	IPR030276	InterPro
PTHR44787	PTHR44787	PANTHER

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