Protein: Q9NRD5 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9NRD5 (Uniprot)	PICK1_HUMAN	PICK1	PRKCA-binding protein	human	No

Protein Function

Uniprot: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating t more..

MoonDB Dissimilar Functions

Showing 1 to 3 of 3 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	132, 142, 219, 354, 527, 694	GO:0007165	signal transduction	831	1.10e-111	5.07e-25
GO:0006725	cellular aromatic compound metabolic process	152	GO:0007165	signal transduction	831	5.44e-126	5.27e-27
GO:0009059	macromolecule biosynthetic process	31, 401	GO:0006793	phosphorus metabolic process	491	1.25e-35	4.53e-23

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
31	GO:0034645	cellular macromolecule biosynthetic process
31	GO:0044271	cellular nitrogen compound biosynthetic process
31	GO:0090304	nucleic acid metabolic process
31	GO:0010468	regulation of gene expression
63	GO:0010467	gene expression
63	GO:0090304	nucleic acid metabolic process
63	GO:0060255	regulation of macromolecule metabolic process
73	GO:0006355	regulation of transcription, DNA-templated
132	GO:0090304	nucleic acid metabolic process
132	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
31	GO:0005634	nucleus
63	GO:0005634	nucleus
73	GO:0005634	nucleus
82	GO:0005634	nucleus
84	GO:0005634	nucleus
89	GO:0005634	nucleus
95	GO:0005634	nucleus
132	GO:0005634	nucleus
135	GO:0005634	nucleus
142	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002092	positive regulation of receptor internalization	ISS
GO:0006468	protein phosphorylation	ISS
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	NAS
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IDA
GO:0015844	monoamine transport	IDA
GO:0021782	glial cell development	ISS
GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	IBA
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	ISS
GO:0036294	cellular response to decreased oxygen levels	ISS
GO:0042149	cellular response to glucose starvation	ISS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IDA
GO:0005794	Golgi apparatus	ISS
GO:0005829	cytosol	IDA
GO:0005856	cytoskeleton	IEA
GO:0005886	plasma membrane	TAS
GO:0014069	postsynaptic density	IEA
GO:0016235	aggresome	IDA
GO:0030054	cell junction	IEA
GO:0030666	endocytic vesicle membrane	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 353 entries

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Interactor	Also a MoonDB EMF protein
4EBP1_HUMAN	No
A0A024R4Z4_HUMAN	No
A4D1I3_HUMAN	No
ABT1_HUMAN	No
AEBP2_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
AKT1_HUMAN	No
AKT2_HUMAN	No
ALKB8_HUMAN	No
AP1M1_HUMAN	No

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Publications Associated

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PMID	Article Title
10591208	The DNA sequence of human chromosome 22.
10623590	Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.
11343649	Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
11641419	The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.
11802773	Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).
12529303	Reevaluating human gene annotation: a second-generation analysis of chromosome 22.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15247289	The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.
15304526	A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth.
15461802	A genome annotation-driven approach to cloning the human ORFeome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
AH	PS50870	PROSITE
AH/BAR_dom_sf	IPR027267	InterPro
AH_dom	IPR010504	InterPro
Arfaptin	PF06456	Pfam
Arfaptin	SM01015	SMART
Arfaptin_fam	IPR030798	InterPro
JC7167	JC7167	PIR
PDZ	IPR001478	InterPro
PDZ	PF00595	Pfam
PDZ	PS50106	PROSITE

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