Protein: Q9QWV4 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9QWV4 (Uniprot)	MLF1_MOUSE	Mlf1	Myeloid leukemia factor 1	mouse	No

Protein Function

Uniprot: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses R more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	1675	GO:0007165	signal transduction	1492	2.28e-48	1.95e-17

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1492	GO:0035556	intracellular signal transduction
1492	GO:0010646	regulation of cell communication
1492	GO:0060255	regulation of macromolecule metabolic process
1492	GO:0023051	regulation of signaling
1675	GO:0034645	cellular macromolecule biosynthetic process
1675	GO:0044271	cellular nitrogen compound biosynthetic process
1675	GO:0010467	gene expression
1756	GO:0071310	cellular response to organic substance
1756	GO:0031324	negative regulation of cellular metabolic process
1756	GO:0010629	negative regulation of gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1492	GO:0005634	nucleus
1492	GO:0005886	plasma membrane
1675	GO:0005829	cytosol
1675	GO:0005634	nucleus
1756	GO:0005829	cytosol
1756	GO:0005730	nucleolus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002318	myeloid progenitor cell differentiation	IDA
GO:0006351	transcription, DNA-templated	IDA
GO:0007050	cell cycle arrest	ISO

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0031514	motile cilium	IDA
GO:0097730	non-motile cilium	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433Z_MOUSE	No
CYBP_MOUSE	No
DYL2_MOUSE	No
EIF3G_MOUSE	No
NRBP_MOUSE	No
NUCL_MOUSE	No

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Publications Associated

Showing 1 to 6 of 6 entries

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PMID	Article Title
10393836	cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia.
10523300	HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1.
12176995	MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.
15122318	Myeloid leukemia factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation.
17008314	Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.
21183079	A tissue-specific atlas of mouse protein phosphorylation and expression.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
Mlf1IP	PF10248	Pfam
Myeloid_leukemia_factor	IPR019376	InterPro
PTHR13105	PTHR13105	PANTHER

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