Protein: Q9UQE7 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9UQE7 (Uniprot)	SMC3_HUMAN	SMC3	Structural maintenance of chromosomes protein 3	human	Yes

Protein Function

Uniprot: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesi more..

Dissimilar Functions Manual Curation

Function 1: Central part of the cohesin complex, required for chromosome cohesion during the cell cycle.

Function 2: Basement membrane-associated chondroitin proteoglycan. Also, is a host cellular ligand of vaccinia virus neurovirulence factor N1L.

Publications (PMID): 9015313, 10375619, 19444697, 17927980

MoonDB Network Modules

Biological Processes

Showing 1 to 9 of 9 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
222	GO:0006139	nucleobase-containing compound metabolic process
222	GO:0060255	regulation of macromolecule metabolic process
222	GO:0007165	signal transduction
432	GO:0007165	signal transduction
776	GO:0006464	cellular protein modification process
776	GO:0035556	intracellular signal transduction
776	GO:0031325	positive regulation of cellular metabolic process
776	GO:0032268	regulation of cellular protein metabolic process
776	GO:0009966	regulation of signal transduction

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Cellular Components

Showing 1 to 7 of 7 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
222	GO:0070013	intracellular organelle lumen
222	GO:0044428	nuclear part
432	GO:0005829	cytosol
432	GO:0005886	plasma membrane
776	GO:0005829	cytosol
776	GO:0043232	intracellular non-membrane-bounded organelle
776	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 11 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000278	mitotic cell cycle	TAS
GO:0006275	regulation of DNA replication	IMP
GO:0006281	DNA repair	IEA
GO:0007062	sister chromatid cohesion	TAS
GO:0019827	stem cell population maintenance	IEA
GO:0032876	negative regulation of DNA endoreduplication	IMP
GO:0044791	positive regulation by host of viral release from host cell	IDA
GO:0051301	cell division	IEA
GO:0051321	meiotic cell cycle	IDA
GO:0051702	interaction with symbiont	IDA

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Cellular Components

Showing 1 to 10 of 14 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000775	chromosome, centromeric region	TAS
GO:0000785	chromatin	IDA
GO:0000800	lateral element	IEA
GO:0005604	basement membrane	TAS
GO:0005622	intracellular	IDA
GO:0005634	nucleus	TAS
GO:0005654	nucleoplasm	TAS
GO:0005694	chromosome	TAS
GO:0005829	cytosol	TAS
GO:0008278	cohesin complex	NAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005604	basement membrane	GO:0005634	nucleus	3.73e-02	1.47e-24

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANR28_HUMAN	No
APC_HUMAN	No
CEP63_HUMAN	No
DISC1_HUMAN	Yes: Q9NRI5 (MoonDB)
FEZ1_HUMAN	No
FEZ2_HUMAN	No
FTM_HUMAN	No
KIFA3_HUMAN	No
MAD1_HUMAN	No
MAD3_HUMAN	No

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Publications Associated

Showing 1 to 10 of 26 entries

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PMID	Article Title
9506951	Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.
11042152	Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
11076961	Characterization of vertebrate cohesin complexes and their regulation in prophase.
11590136	A potential role for human cohesin in mitotic spindle aster assembly.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164054	The DNA sequence and comparative analysis of human chromosome 10.
15656913	Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3.
15837422	Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.
17105772	The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.
17273969	Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation.

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OMIM Diseases Associated

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OMIM ID	Disease Name
610759	Cornelia de Lange syndrome 3

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Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
P-loop_NTPase	IPR027417	InterPro
RecF/RecN/SMC_N	IPR003395	InterPro
SMC	IPR024704	InterPro
SMC	PIRSF005719	PIRSF
SMC_hinge	IPR010935	InterPro
SMC_hinge	PF06470	Pfam
SMC_hinge	SM00968	SMART
SMC_hinge_sf	IPR036277	InterPro
SMC_N	PF02463	Pfam
SSF52540	SSF52540	SUPFAM

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