Protein: Q9GZM8 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9GZM8 (Uniprot)	NDEL1_HUMAN	NDEL1	Nuclear distribution protein nudE-like 1	human	No

Protein Function

Uniprot: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	353	GO:0019538	protein metabolic process	393	1.88e-02	4.66e-37
GO:0044260	cellular macromolecule metabolic process	127	GO:0051641	cellular localization	872	4.50e-03	3.02e-89

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
36	GO:0022607	cellular component assembly
67	GO:0060255	regulation of macromolecule metabolic process
127	GO:0016070	RNA metabolic process
127	GO:0010467	gene expression
223	GO:0022607	cellular component assembly
223	GO:0007165	signal transduction
319	GO:0060255	regulation of macromolecule metabolic process
353	GO:0000398	mRNA splicing, via spliceosome
393	GO:0044267	cellular protein metabolic process
826	GO:0022607	cellular component assembly

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
36	GO:0005829	cytosol
36	GO:0005815	microtubule organizing center
67	GO:0005634	nucleus
84	GO:0005634	nucleus
95	GO:0005634	nucleus
127	GO:0005634	nucleus
223	GO:0005634	nucleus
232	GO:0005829	cytosol
232	GO:0043232	intracellular non-membrane-bounded organelle
319	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000132	establishment of mitotic spindle orientation	IBA
GO:0001764	neuron migration	IEA
GO:0001833	inner cell mass cell proliferation	IEA
GO:0006508	proteolysis	IEA
GO:0007020	microtubule nucleation	IBA
GO:0007059	chromosome segregation	IMP
GO:0007062	sister chromatid cohesion	TAS
GO:0007100	mitotic centrosome separation	IBA
GO:0008090	retrograde axonal transport	IEA
GO:0008286	insulin receptor signaling pathway	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000776	kinetochore	IDA
GO:0000777	condensed chromosome kinetochore	IEA
GO:0005635	nuclear envelope	IEA
GO:0005813	centrosome	IBA
GO:0005819	spindle	IEA
GO:0005829	cytosol	TAS
GO:0005871	kinesin complex	IBA
GO:0005874	microtubule	IEA
GO:0008021	synaptic vesicle	IEA
GO:0031252	cell leading edge	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433E_HUMAN	Yes: P62258 (MoonDB)
1433G_HUMAN	No
ABI3_HUMAN	No
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
AF10_HUMAN	No
AF17_HUMAN	No
AIMP2_HUMAN	No
ANK2_HUMAN	No
BMI1_HUMAN	No
BORC6_HUMAN	No

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Publications Associated

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PMID	Article Title
11163260	NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein.
12506198	Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
12556484	Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.
12812986	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
14962739	Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
14970193	Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15572112	Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
15728732	Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
NDEL1	IPR033493	InterPro
NUDE	IPR033494	InterPro
NUDE_C	PF04880	Pfam
NUDE_dom	IPR006964	InterPro
PTHR10921	PTHR10921	PANTHER
PTHR10921:SF0	PTHR10921:SF0	PANTHER

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